Роль K+ - каналов в вазорелак- сантном действии алкалоидов 1-О-бензоилнапеллина и 6-О-бензоилгетератизина на аорты крысы

Authors

  • А.Т Есимбетов

    Нукусский филиал Самаркандского института ветеринарной медицины

  • Б Кунисов

    Нукусский филиал Самаркандского института ветеринарной медицины

  • А.А Зарипов

    Karakalpak State University image/svg+xml

  • M Бакиева

    Namangan State University image/svg+xml

  • П.Б Усманов

    Институт биофизики и биохимии при НУУ

  • М Султанходжаев

    Институт химии растительных веществ АН РУз

Keywords: diterpenoid alkaloid, rat aorta, smooth muscles, K+ -channel, glibenclamide

Abstract

In our investigation the relaxant effect of the alkaloids 1-O-benzoylnapelline and 6-O-benzoylgeteratizine on the rat aorta was stud- ied. These alkaloids effectively relax the aortic contraction induced by KCI (30 mM). It would be concluded that the glibenclamide sig- nificantly reduces the relaxing effect of alkaloids on the basis of it, and can be assumed that the activation of ATP-dependently potassium channels which is involved in the mechanism of action. In contrast to glibenclamide, the effects of TEA, BaCl and 4-aminopyridine on relaxation caused by 1-O-benzoylnapelline and 6-O-benzoylheteratisine were less pronounced and did not significantly affect this pro- cess. This indicates that these alkaloids do not significantly affect the activity of K , K+ , and K channels of rat aortic smooth muscle ca V IR cells.

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