Kversetin-3-o-β-(3”-galloil)-glyukopiranozid flavonoidining inotrop va kardioprotektor ta’siri

Authors

  • Armanali Abdinagievich Abdijaliev

    Nukus State Pedagogical Institute named after Ajiniyaz image/svg+xml

  • Inoyat Zulfiqorovich Jumaev

    Institute of Biophysics and Biochemistry under the National University of Uzbekistan

  • Sadriddin Nurillaevich Boboev

    Institute of Biophysics and Biochemistry under the National University of Uzbekistan

  • Shaxnoza Baxtiyarovna Qurbonova

    Institute of Biophysics and Biochemistry under the National University of Uzbekistan

  • Polat Bekmuratovich Usmanov

    Institute of Biophysics and Biochemistry under the National University of Uzbekistan

  • Rustamjon Rasuljonovich Maxmudov

    Institute of Bioorganic Chemistry of the Academy of Sciences of the Republic of Uzbekistan

  • Gulshat Sultamuratovna Berdibaeva

    Uzbek State University of Physical Culture and Sport image/svg+xml

Keywords: cardiac muscle, hypoxia, flavonoid and ion channels

Abstract

The article examined the effect of the flavonoid quercetin-3-O-β-(3″-galloyl)-glucopyranoside on the contractile activity of rat heart papillary muscle. It was found that this flavonoid exerts a positive inotropic effect on the contractile activity cardiac papillary muscle of rat. It was described that the positive inotropic effect of the flavonoid quercetin-3-O-β-(3″-galloyl)-glucopyranoside on myocardial contractile activity is mediated via activation of Na+ channels in the membranes of cardiac muscle cells.

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